New dry eye study (Study ID: ORCHID)

What are we trying to learn?

This study is investigating the amount of Proteoglycan 4 (PRG4), which is a lubricating protein found on the ocular surface in patients with and without dry eye symptoms. We will be collecting tears from your eyes and surface cells from your conjunctiva, which is the white part of your eye. Data will be collected from three distinct groups:

Group A: Non-dry eye participants

Group B: Dry eye participants

Group C: Participants with Sjӧgren’s syndrome who suffer from severe dry eye

About the study

If eligible, you will be asked to follow the study instructions and attend the following visit. All 3 groups will follow the same visit schedule below.

Visit 1 – Screening, sample collection, & study exit – 1.5 hours

Total time commitment1.5 hours

The visit will include standard clinical procedures that you might encounter when you attend an eye exam. We will be collecting tear samples and a small sample of superficial cells from your conjunctiva, by briefly placing a piece of filter paper on the white part of your eye.

What are the requirements?

  • You are at least 18 years of age,
  • Have not worn contact lenses in either eye in the past 6 months, and
  • You are willing and able to follow instructions and maintain the appointment schedule

How to participate

If you are interested in participating, please email corestudies@uwaterloo.ca and write the study ID, “ORCHID” as the email title. If you have questions or would like more details, please call 519-888-4742.

You will be provided with all relevant study information prior to study enrollment and you are under no obligation to participate.