What are we trying to learn?
Nearsightedness or “myopia” makes it difficult to see distant objects clearly and requires the use of glasses or contact lenses to achieve good vision. Typically the severity of this myopia increases as children grow, which may increase their risk of vision threatening conditions, such as glaucoma, retinal detachment and blindness later in life. A recent clinical trial of a specially designed contact lenses, called MiSight®, showed significant slowing of myopia progression in children aged 8-12. The MiSight® lens is now commercially available in Canada.
The purpose of this study is to investigate if a new design of these MiSight® soft contact lenses could provide a greater treatment effect, particularly for children whose myopia progresses quickly.
About the study
This study consists of two parts. In Part 1 (the first year), all children will wear the MiSight® myopia control lens, which has been approved for commercial use in Canada. In Part 2 (the final two years), your child will wear one of three lens types, all of which are designed to slow myopia progression. One of these three lens types is MiSight®, the other two lenses are not commercially available but have been approved by Health Canada to be assessed in this study.
At the beginning of study, you child will be randomly assigned to the type of lenses they will wear during Part 2 of the study.
- Visit 1a &1b (both visits normally combined): Baseline measurements (3.5 hours) and trial lens fit, dispensing Part 1 lenses (1.5 hours) – total time 5 hours
- Visit 2: 2-week follow up – 2 hours
- Visit 3: 3-month follow up – 1.50 hour
- Visit 4: 6-month follow up –1.75 hours
- Visit 5: 12-month follow up & dispense Part 2 lenses – 3.75 hours
- Visit 6: 2-week follow up – 1.75 hour
- Visit 7: 6-month follow up – 2 hours
- Visit 8: 12-month follow up – 3.75 hours
- Visit 9: 18-month follow up – 2 hours
- Visit 10: 24-month follow up and study exit – 3.75 hours
Total time commitment – 10 visits for a total of 27.25 hours over 3 years
The visits will include standard clinical procedures that you might encounter when you attend an eye exam.
What are the requirements?
- Children aged 7-11
- No previous experience with myopia control treatments
- Prescription range between -0.50 and -4.50 D
- Willing to wear daily disposable contact lenses 10 hours/day, 6 days/week
In appreciation of your time, you will receive $545 upon study completion. Parking tokens will be provided as needed.
How to participate
If you are interested in participating, or would like to book your first appointment, please contact CORE at 519-888-4742 or email COREstudies@uwaterloo.ca for more information.
Please provide the study ID “MAP” when you call/email. You will be provided with all relevant study information prior to study enrollment and you are under no obligation to participate.
Safety during COVID-19
We want to let you know that we have revised several of our protocols to keep participants and researchers safe during the pandemic, including enhanced cleaning and mandatory wearing of masks by everyone. Measures we have taken to reduce the risk of exposure to COVID-19 are explained in the “Information Letter: COVID-19 Risks for In-Person Research Study Visits” which we will ask you to sign in the event your child participates.