Category Archives: dry eye study

SEAHORSE: Specialty contact lens study for dry eye

The objective of this study is to determine if specialty contact lenses with and without a “HydraPEG” lens coating can improve symptoms of dry eye. These specialty scleral lenses rest on the white part of the eye (sclera). Due to their design and fitting, they can help relieve ocular discomfort and dryness in dry eye patients. For this study we are looking for symptomatic soft lens wearers and non-lens wearers to be fit with these lenses.

Both dry eye and non-dry eye participants are being recruited as part of this study. Participants in the non-dry eye group are being invited to join a control group of people without dry eye. Participants in the non-dry eye group will be selected based on their age and biological sex to match a corresponding participant in the dry eye group.

About the study

This study involves at least 6 in-office visits.  The visits are:

  • Visit 1 – Screening visit to determine eligibility 2hr 30min
  • Visit 2 Dispense study lens type #1 and lens training 2hr 30min
  • Visit 3 – 2-week follow up of study lens type #1 1hr
  • Visit 4 – 1-month follow up of study lens type #1 and dispense study lens type #1 2hr
  • Visit 5 – 2-week follow up of study lens type #2 1hr
  • Visit 6 – 1-month follow up of study lens type #2 and study exit 1hr 30min

Total in-office visit time commitmentestimated 10.5 hours

There are some questionnaires to be completed between study visits, estimated time commitment of 1 hour spread across the study period.

The visits will include standard clinical procedures that you might encounter when you attend an eye exam.

Participant requirements

  • Age: At least 18 years old and have full legal capacity to volunteer
  • Experiences symptoms of dry eye (symptomatic)
  • In good ocular and general health and a full eye exam conducted in the last 2 years
  • Have a prescription of sphere between +20.00 and -20.00D AND astigmatism up to -3.00DC in each eye
  • Anticipate being able to wear the study lenses for at least 8 hours per day, 5 days per week for the duration of the study

Reimbursement

In appreciation of your time, you will receive $230 for completing 6 in-office, plus an additional $20 per hours if a lens modification is needed. All study contact lenses and solutions will be provided at no cost. If applicable, parking tokens will be provided.

How to participate

If you have questions about this study or would like more information, please call us on 519-888-4742 or email us at corestudies@uwaterloo.ca and mention the study name SEAHORSE.

If you are interested in participating, please create a volunteer profile at the link below and we will contact you with more information.  If you are already a registered CORE volunteer, please contact us using the link below and mention the study name SEAHORSE.

All studies conducted at CORE have been reviewed and received ethics clearance through a University of Waterloo Research Ethics Board.

HEINZ: Recruiting participants with dry eye for specialty contact lens study

The objective of this study is to evaluate (compare) the ocular effects of two types of specialty (scleral) contact lenses and determine if they improve symptoms of dry eye. Two pairs of scleral lenses (one pair with a specialized coating on the surface, one pair without) will be worn during the study period.

We are looking for symptomatic lens wearers AND non-lens wearers who experience dry eye symptoms, aged 18 or older, to participate in this study. We will custom-fit these specialty scleral lenses, which rest on the white part of the eye (sclera). Due to their custom design and larger fit, these lenses are commonly used for dry eye management and can help relieve ocular discomfort in dry eye patients, including those who may have discontinued using soft contact lenses due to discomfort.

About the study

This study has 5 in-clinic visits spread across approximately a 2-month study duration:

  • Visit 1 (0-0) – Screening and baseline measurement and custom lenses ordered – 2.5hrs
  • Visit 2 (1-1) – Lens 1 delivery, training & assessments– 2 hrs
  • Visit 3 (1-2) – Lens 1 follow-up visit after 4 weeks – 1.5 hrs
    Wash-out period
  • Visit 4 (2-1) – Lens 2 delivery & assessments – 1.5hrs
  • Visit 5 (2-2) – Lens2 follow-up visit after 4 weeks – 1.5hrs

Total in-visit time commitment9 hours

You will also be asked to complete 3 short questionnaires in between study visits (<1 hour total across the study).

The visits will include standard clinical procedures that you might encounter when you attend a routine eye exam. On each visit, both eyes will be assessed with and without contact lenses on the eye. Images will be taken with a series of instruments, and tear film samples will be collected using small strips designed for tear film analysis.

Participant requirements

  • Adults, aged 18 years or older
  • Experiences symptoms of dry eye (symptomatic)
  • In good ocular and general health and has had a full eye exam in the last 2 years
  • Has a prescription of sphere between +20.00 and -20.00DS AND astigmatism up to-3.00DC in each eye
  • Anticipates being able to wear the study lenses for at least 8 hours per day, 7 days per week, for the duration of the study

Reimbursement

In appreciation of your time, you will receive $180 upon study completion. All study contact lenses and solutions will be provided. Parking passes will be provided as required.

How to participate

If you are interested in participating, please complete and return the attached pre-screening questionnaires by email to hotchere@uwaterloo.ca.

For more information on the HEINZ study, visit http://COREstudies.ca/HEINZ .

If you have questions or would like more details, please contact me at hotchere@uwaterloo.ca. You will be provided with all relevant study information prior to study enrollment, and you are under no obligation to participate.

This study has been reviewed and received ethics clearance through a University of Waterloo Research Ethics Board.

OCTOPUS: Seeking non-lens wearers with & without dry eye

Dry eye disease (DED) is a common ocular condition affecting up to 75% of the population and can severely impact patient quality of life. There is a need for more specific tests to diagnosis dry eye disease. The purpose of this study is to investigate the use of an ocular thermography test that measures the surface temperature of the eye using a special camera to diagnose dry eye. It will also assess if a biomarker test that looks at chemical components and antibodies in the tear film can be used to diagnose dry eye.

Both dry eye and non-dry eye participants are being recruited as part of this study. Participants in the non-dry eye group are being invited to join a control group of people without dry eye. Participants in the non-dry eye group will be selected based on their age and biological sex to match a corresponding participant in the dry eye group.

About the study

This study involves 2 study visits, over 2 consecutive days.

  • Visit 1 – Screening and DED assessments – 2.5 hours
  • Visit 2 – Additional DED assessments and study exit – 2.0 hours

Total time commitment for visits = 4.5 hours over 2 days (use of any dry eye treatments/tear drops are not permitted on the study days)  

This study will include 2 in-clinic visits over 2 consecutive days (total = 4.5 hrs) and involve collecting the tear film from your eyes and taking pictures of your eyes with a thermal imaging camera in addition to standard optometric assessments that would occur during an eye exam (including application of an eye drop and procedures that involve something touching the eye).

Participant requirements

  • You are at least 17 years of age
  • You have not worn any contact lenses in the past 6 months
  • You are not experiencing ocular allergies
  • You are not on any allergy medications or any medicated eyedrops
  • You have had an eye exam in the past 2 years
  • Dry eye group: You have a history of DED and/or using tear drops for at least the past 3 months
  • Non-dry eye group: You have no previous history of DED and no history of using any tear drops in the past

Reimbursement

In appreciation of your time, you will receive $20 per hour you are involved in the study ($90 upon completion). Parking tokens are available for those who drive to their visits.

How to participate

If you are interested in participating, please create a volunteer profile at the link below and we will contact you with more information. If you are already a registered CORE volunteer, please email COREstudies@uwaterloo.ca and mention the study name OCTOPUS. You will be provided with all relevant study information prior to study enrollment, and you are under no obligation to participate.

All studies conducted at CORE have been reviewed and received ethics clearance through a University of Waterloo Research Ethics Board.

PLUM: Dry eye study with gummy bear oral supplement use

Dry eye symptoms are commonplace. Dry eye is often managed with lubricating eye drops, stopping tears from draining or by stimulating tear production. Recently, there has been a shift toward focusing on nutrition for dry eye, especially with regard to oral antioxidants for relieving dry eye symptoms. This study will investigate the effectiveness of an oral supplement in form of a gummy bear containing blueberry powder.

The study consists of 3 in-office study appointments and 2 telephone calls, totaling 4.5 hours over 4 weeks.

What are the requirements?

  • You are at least 18 years of age.
  • You have dry eyes
  • You have not worn any contact lenses in the past 3 months
  • You have not used an oral supplement containing antioxidants in the past 3 months

Reimbursement

In appreciation of your time, you will receive $20 per hour you are involved in the study (up to $90). All study products will also be provided, and parking tokens are available for those who drive to their visits.

How to participate

If you are interested in participating, please email corestudies@uwaterloo.ca with the subject line “PLUM” or call 519-888-4742 for more information. You will be provided with all relevant study information prior to study enrollment and you are under no obligation to participate.

COLLIE: Contact lens comfort study

What are we trying to learn?

Xiidra (lifitegrast 5.0% ophthalmic solution) is a Health Canada approved eye drop that has been shown to be effective in relieving dryness symptoms in individuals with dry eye disease. The purpose of this study is to evaluate changes in comfort and dryness in contact lens wearers after using Xiidra for 12 weeks.

About the study

If eligible, you will be asked to follow the study instructions and attend the following visits.

• Visit 1 – Screening to determine eligibility – 0.75 hour
• Visit 2 – Baseline measurements and dispense eye drops – 1 hour
• Visit 3 – 2-week follow-up visit– 1 hour
• Visit 4 – 6-week follow-up visit– 1 hour
• Visit 5 – 12-week follow-up visit– 1 hour
Total time commitment – 4.75 hours
The visits will include standard clinical procedures that you might encounter when you attend an eye exam.

What are the requirements?

• You are 18 years or older
• You have worn soft contact lenses for a minimum of 5 days/week for 6 hours/day over the past month (and are willing to continue to do so)
• You experience discomfort (e.g. dryness) when wearing your contact lenses

Reimbursement

In appreciation of your time you will receive $95 upon study completion. Parking passes will be provided as required.

How to participate

If you are interested in participating, please complete and return the attached questionnaire to corestudies@uwaterloo.ca and write the study ID, “COLLIE”, as the email title. If you have questions or would like more details, please call 519-888-4742. You will be provided with all relevant study information prior to study enrollment and you are under no obligation to participate.

Safety during COVID-19

We want to let you know that we have revised several of our protocols to keep participants and researchers safe during the pandemic, including enhanced cleaning and mandatory wearing of masks by everyone. Measures we have taken to reduce the risk of exposure to COVID-19 are explained in the attached “Information Letter: COVID-19 Risks for In-Person Research Study Visits” which we will ask you to sign in the event you participate. Please note that you will be within 2m (6 feet) of the researcher during some or most of the study visit time. At all times, the furthest possible distance will be maintained. Please note, if you are aged 60 and above, you are considered at a greater risk for severe illness from the COVID-19 virus.

CORGI: Seeking contact lens wearers with dry eye symptoms

What are we trying to learn?

The purpose of this study is to refit wearers of daily disposable contact lenses who currently experience symptoms of dry eye and discomfort during lens wear, with a different type of daily disposable contact lens.

We will evaluate the performance of your habitual lenses and the study lenses by taking measurements and asking you questions about your lens wearing experience.

About the study

If eligible, you will be asked to follow the study instructions and attend the following visits:

  • Visit 1 – Screening to determine eligibility– 1.5 hour
  • 1 week of habitual lens wear
  • Visit 2 – Baseline measurement & study lens dispense – 1 hour
  • 1 month of study lens wear
  • Visit 3 –1-month-follow-up visit & study exist – 1 hour


Total time commitment4.5 hours (3.5 hours of study visits plus 1 additional hour for at-home ratings)

The visits will include standard clinical procedures that you might encounter when you attend an eye exam.

What are the requirements?

  • You are at least 17 years of age
  • You are currently wearing daily disposable contact lenses at least 1 day a week and experience symptoms of dryness or discomfort
  • You are willing to wear daily disposable contact lenses at least 3 days a week for the duration of the study.
  • You are willing and able to follow instructions and maintain the appointment schedule

Reimbursement

In appreciation of your time you will receive up to $90. Parking passes will be provided as required.

How to participate

If you are interested in participating, please email corestudies@uwaterloo.ca with the subject line: CORGI.  You will be provided with all relevant study information prior to study enrolment and you are under no obligation to participate.