Category Archives: adults aged 17+

OCTOPUS: Seeking non-lens wearers with & without dry eye

Dry eye disease (DED) is a common ocular condition affecting up to 75% of the population and can severely impact patient quality of life. There is a need for more specific tests to diagnosis dry eye disease. The purpose of this study is to investigate the use of an ocular thermography test that measures the surface temperature of the eye using a special camera to diagnose dry eye. It will also assess if a biomarker test that looks at chemical components and antibodies in the tear film can be used to diagnose dry eye.

Both dry eye and non-dry eye participants are being recruited as part of this study. Participants in the non-dry eye group are being invited to join a control group of people without dry eye. Participants in the non-dry eye group will be selected based on their age and biological sex to match a corresponding participant in the dry eye group.

About the study

This study involves 2 study visits, over 2 consecutive days.

  • Visit 1 – Screening and DED assessments – 2.5 hours
  • Visit 2 – Additional DED assessments and study exit – 2.0 hours

Total time commitment for visits = 4.5 hours over 2 days (use of any dry eye treatments/tear drops are not permitted on the study days)  

This study will include 2 in-clinic visits over 2 consecutive days (total = 4.5 hrs) and involve collecting the tear film from your eyes and taking pictures of your eyes with a thermal imaging camera in addition to standard optometric assessments that would occur during an eye exam (including application of an eye drop and procedures that involve something touching the eye).

Participant requirements

  • You are at least 17 years of age
  • You have not worn any contact lenses in the past 6 months
  • You are not experiencing ocular allergies
  • You are not on any allergy medications or any medicated eyedrops
  • You have had an eye exam in the past 2 years
  • Dry eye group: You have a history of DED and/or using tear drops for at least the past 3 months
  • Non-dry eye group: You have no previous history of DED and no history of using any tear drops in the past

Reimbursement

In appreciation of your time, you will receive $20 per hour you are involved in the study ($90 upon completion). Parking tokens are available for those who drive to their visits.

How to participate

If you are interested in participating, please create a volunteer profile at the link below and we will contact you with more information. If you are already a registered CORE volunteer, please email COREstudies@uwaterloo.ca and mention the study name OCTOPUS. You will be provided with all relevant study information prior to study enrollment, and you are under no obligation to participate.

All studies conducted at CORE have been reviewed and received ethics clearance through a University of Waterloo Research Ethics Board.

BAGPIPES: Seeking DD hydrogel contact lens wearers

Seeking daily disposable contact lens wearers aged 17-60. Sleeping or napping in contact lenses limits the amount of oxygen reaching the eyes, making the cornea (front of the eye) swell more than it would during waking hours. In this study, we want to simulate sleeping in contact lenses by placing an eye patch over one eye that is wearing a contact lens during waking hours to measure the amount of swelling that occurs.

About the study

If eligible, you will be asked to follow the study instructions and attend the following visits:

  • Visit 1 (DAY 1) – Screening and study measurements – 2.75 hours
  • Visit 2 (DAY 2) – Baseline assessment and lens dispense – 1.25 hours
    *3 hour wait time between Visit 2 & 3 with eye patch covering one eye*
  • Visit 3 – Lens removal after 3 hr wait time and measurement taken (same day)
  • Visit 4 – Measurement taken after 0.5 hr from removal (same day)
  • Visit 5 – Measurement taken after 1 hr from removal (same day)
  • Visit 6 – Measurement taken after 2 hr from removal (same day)
  • Visit 7 – Measurement taken after 3 hr from removal then study exit (same day)
    *Visits 3-7 will take 4.5 hours

Total time commitment 11.5 hours over 2 days

The visits will include standard clinical procedures that you might encounter when you attend an eye exam.

What are the requirements?

  • To be eligible for this study, you must meet the following criteria:
  • Must be between 17-60 years of age
  • Have proof of eye examination within the last 2 years
  • Prescription between +4.00 and -8.00
  • No previous history of overnight contact lens wear
  • Have worn either spherical hydrogel or spherical silicone hydrogel contact lenses for the past 3 consecutive years with wearing daily disposable contact lenses of the same material type (hydrogel or silicone hydrogel, respectively) currently and at least in the past 6 months. 
  • Are currently not pregnant or nursing a child
  • Have NOT undergone eye surgery
  • Have a habitual contact lens wear schedule of at least 8 hrs a day, 5 days a week
  • Have a wearable pair of spectacles

Reimbursement

In appreciation of the time involved, you will receive up to $230. Parking passes will be provided as required.

Safety during COVID-19

We want to let you know that we have revised several of our protocols to keep participants and researchers safe during the pandemic, including enhanced cleaning and mandatory wearing of masks by everyone. Measures we have taken to reduce the risk of exposure to COVID-19 are explained in an “Information Letter: COVID-19 Risks for In-Person Research Study Visits” which we will ask you to sign in the event you participate.

Please note that you will be within 2m (6 feet) of the researcher during some or most of the study visit time.  At all times, the furthest possible distance will be maintained.

Please note, if you are aged 60 and above, you are considered at a greater risk for severe illness from the COVID-19 virus.

How to participate

If you are interested in participating, please create a volunteer profile at the link below and we will contact you with more information. If you are already a registered CORE volunteer, please email corestudies@uwaterloo.ca and mention the study name BAGPIPES. You will be provided with all relevant study information prior to study enrollment and you are under no obligation to participate.

CORGI: Seeking contact lens wearers with dry eye symptoms

What are we trying to learn?

The purpose of this study is to refit wearers of daily disposable contact lenses who currently experience symptoms of dry eye and discomfort during lens wear, with a different type of daily disposable contact lens.

We will evaluate the performance of your habitual lenses and the study lenses by taking measurements and asking you questions about your lens wearing experience.

About the study

If eligible, you will be asked to follow the study instructions and attend the following visits:

  • Visit 1 – Screening to determine eligibility– 1.5 hour
  • 1 week of habitual lens wear
  • Visit 2 – Baseline measurement & study lens dispense – 1 hour
  • 1 month of study lens wear
  • Visit 3 –1-month-follow-up visit & study exist – 1 hour


Total time commitment4.5 hours (3.5 hours of study visits plus 1 additional hour for at-home ratings)

The visits will include standard clinical procedures that you might encounter when you attend an eye exam.

What are the requirements?

  • You are at least 17 years of age
  • You are currently wearing daily disposable contact lenses at least 1 day a week and experience symptoms of dryness or discomfort
  • You are willing to wear daily disposable contact lenses at least 3 days a week for the duration of the study.
  • You are willing and able to follow instructions and maintain the appointment schedule

Reimbursement

In appreciation of your time you will receive up to $90. Parking passes will be provided as required.

How to participate

If you are interested in participating, please email corestudies@uwaterloo.ca with the subject line: CORGI.  You will be provided with all relevant study information prior to study enrolment and you are under no obligation to participate.