Category Archives: Current Studies

Online Myopia Focus Group for Children – STUDY ID: CLAM

About the study

Myopia, or near-sightedness, is a condition that emerges during childhood and continues to progress throughout adolescence.

This study will be conducted remotely avoiding in-person meetings. The purpose of this study is to gain insights into vision related questionnaires, based on the responses from, and understanding of these questionnaires by, myopic children. These vision related questionnaires are specifically designed and adapted to evaluate the quality of vision and visual abilities in children. We want to hear from your child if there are any difficult questions, words or concept in these questionnaires and if they think we should be asking additional questions.

If eligible at the Screening visit, your child will be asked to attend one online focus group interview (small group discussion) with a moderator experienced in conducting interviews with children The interviews will be video-recorded and will take place during early evening or weekends. We will work with you to schedule a convenient time. These video-recordings will be encrypted and stored by the study sponsor for 5 years.

Total time commitment is less than 4 hours.

  • Screening Up to 1 hour: You and your child will attend a TEAMS video conferencing meeting with a researcher from CORE which will not be recorded. During this meeting we will explain the study and answer your questions. We will ask you both to sign the consent documents that we will mail to you ahead of time and also request your consent to request vision related information from your child’s optometrist.
  • Home tasksUp To 1 hour: We will mail you paper questionnaires for your child to review and make notes on regarding any difficult questions or unclear words. We will also ask your child to complete the questionnaires online. You may help them with these tasks. 
  • Focus group interview – Up To 1.5 hours: You will assist your child to access the ZOOM video conferencing platform where they and up to 3 other similar aged children will discuss the questions with a moderator. Your child should have the paper questionnaires and notes to look at during this interview.

What are the requirements?

  • Age 8 to 12 years, inclusive
  • Myopic with good vision; prescription between -0.75 and -4.00 D
  • Astigmatism must be less than or equal to 0.75D
  • Be in good health
  • Have access to a device for video conferencing

Reimbursement

Your child will receive $80 for completing the CLAM study.

How to participate

If you and your child are interested in participating, please create a volunteer profile for your child at the link below and we will contact you with more information. If you are already a registered CORE volunteer, please email corestudies@uwaterloo.ca and mention the study name CLAM. You will be provided with all relevant study information prior to study enrollment and you are under no obligation to participate.

All studies conducted at CORE have been reviewed and received ethics clearance through a University of Waterloo Research Ethics Board.

Safety during COVID-19

We want to let you know that we have revised several of our protocols to keep participants and researchers safe during the pandemic, including enhanced cleaning and mandatory wearing of masks by everyone. Measures we have taken to reduce the risk of exposure to COVID-19 are explained in an “Information Letter: COVID-19 Risks for In-Person Research Study Visits” which we will ask you to sign in the event you participate.

Please note that you will be within 2m (6 feet) of the researcher during some or most of the study visit time.  At all times, the furthest possible distance will be maintained.

Please note, if you are aged 60 and above, you are considered at a greater risk for severe illness from the COVID-19 virus.

Recruiting contact lens wearers for a new study: SETTER

What are we trying to learn?

Specific cells found in the cornea (the front surface of the eye) play an important role in keeping our eyes healthy.

The purpose of this study is to measure these specific cells in participants who normally wear contact lenses. We are looking for participants who experience discomfort while wearing their lenses, and those who do not experience any discomfort with lens wear.

About the study

You will be wearing your own contact lenses throughout this study. This study will be conducted over approximately 3 weeks. There are 10 study visits, which occur on 6 study days. The study visits are:

  • Day1:
    o Visit #1 – Screening visit to determine eligibility (45 minutes)
  • Day 2: No contact lens wear on this day (1.5 hours total)
    o Visit #2 – Eye imaging (45 minutes)
    o Visit #3 –Eye imaging 8 hours after Visit 2 (45 minutes)
  • Day 3: Contact lenses to be worn for 1 hour prior to appointment
    o Visit #4 Eye imaging (45 minutes)
  • Day 4: Contact lenses to be worn for 4 hours prior to appointment
    o Visit #5 – Eye imaging (45 minutes)
  • Day 5: Contact lenses to be worn for 8 hours prior to appointment
    o Visit #6 – Eye imaging (45 minutes)
  • Day 6 Contact lenses to be worn all day (1.75 hours total)
    o Visit #7 – Eye imaging 1 hour after lens insertion (30 minutes)
    o Visit #8 – Eye imaging 4 hours after lens insertion (30 minutes)
    o Visit #9 – Eye imaging 8 hours after lens insertion and study exit (45 minutes)

Total time commitment 6.5 hours

The visits will include standard clinical procedures that will touch your eyes that you might encounter when you attend an eye exam.

What are the requirements?

  • You are at least 17 years of age
  • You habitually wear soft contact lenses at least 5 days per week, 8 hours per day
  • You have worn contact lenses on a daily wear basis for the past 12 months

Reimbursement

You will receive up to $130 for the completion of all study visits. If you drive to your appointments, parking tokens will be provided.

How to participate

If you are interested in participating, please complete and return the attached questionnaire to corestudies@uwaterloo.ca and use the study code name SETTER as the email subject. If you have questions or would like more details, please call 519-888-4742. You will be provided with all relevant study information prior to study enrollment and you are under no obligation to participate.

Safety during COVID-19

We want to let you know that we have revised several of our protocols to keep participants and researchers safe during the pandemic, including enhanced cleaning and mandatory wearing of masks by everyone. Measures we have taken to reduce the risk of exposure to COVID-19 are explained in an “Information Letter: COVID-19 Risks for In-Person Research Study Visits” which we will ask you to sign in the event you participate.

Please note that you will be within 2m (6 feet) of the researcher during some or most of the study visit time.  At all times, the furthest possible distance will be maintained.

Please note, if you are aged 60 and above, you are considered at a greater risk for severe illness from the COVID-19 virus.

Recruiting for new contact lens users with no prior lens experience: SALUKI

1 in 4 new contact wearers stop using contacts within twelve months, often citing handling issues. The purpose of this study is to compare a relatively new contact lens to another lens on the market to see if there are differences in the handling experience with these two lens types.

About the study

If eligible, you will be asked to follow the study instructions and attend the following visits:

Visit 1 – Screening, lens insertion training and lens dispensing visit – 2 hours

  • Optional: Additional lens handling training – 1 hour
  • Visit 2 – 1-week-follow-up visit & study exit – 0.75 hour

    Total time commitment2.75 hours  (3.75 hours if additional lens handling training is required)

    The visits will include standard clinical procedures that you might encounter when you attend an eye exam. You will also be trained in the use of inserting and removing contact lenses.

    What are the requirements?

    • You are between 18 and 40 years of age
    • You have no previous experience with inserting or wearing contact lenses
    • You are willing to learn how to insert and remove contact lenses and to wear the study contacts for a week on a daily disposable basis

    Reimbursement

    In appreciation of your time you will receive up to $55. (You will receive an extra $20 if an additional visit for lens handling training is required.) Parking passes will be provided as required.

    How to participate

    If you are interested in participating, please call 519-888-4742 and provide the study ID: SALUKI.  You will be provided with all relevant study information prior to study enrollment and you are under no obligation to participate. 

    Safety during COVID-19

    We want to let you know that we have revised several of our protocols to keep participants and researchers safe during the pandemic, including enhanced cleaning and mandatory wearing of masks by everyone. Measures we have taken to reduce the risk of exposure to COVID-19 are explained in an “Information Letter: COVID-19 Risks for In-Person Research Study Visits” which we will ask you to sign in the event you participate.

    Please note that you will be within 2m (6 feet) of the researcher during some or most of the study visit time.  At all times, the furthest possible distance will be maintained.

    Please note, if you are aged 60 and above, you are considered at a greater risk for severe illness from the COVID-19 virus.

    Dry Eye Study (Study ID: PLUM)

    Dry eye symptoms are commonplace. Dry eye is often managed with lubricating eye drops, stopping tears from draining or by stimulating tear production. Recently, there has been a shift toward focusing on nutrition for dry eye, especially with regard to oral antioxidants for relieving dry eye symptoms. This study will investigate the effectiveness of an oral supplement in form of a gummy bear containing blueberry powder.

    The study consists of 3 in-office study appointments and 2 telephone calls, totaling 4.5 hours over 4 weeks.

    What are the requirements?

    • You are at least 18 years of age.
    • You have dry eyes
    • You have not worn any contact lenses in the past 3 months
    • You have not used an oral supplement containing antioxidants in the past 3 months

    Reimbursement

    In appreciation of your time, you will receive $20 per hour you are involved in the study (up to $90). All study products will also be provided, and parking tokens are available for those who drive to their visits.

    How to participate

    If you are interested in participating, please email corestudies@uwaterloo.ca with the subject line “PLUM” or call 519-888-4742 for more information. You will be provided with all relevant study information prior to study enrollment and you are under no obligation to participate.

    New contact lens study for young adults (Study ID: MULBERRY)

    Despite improvements in contact lens materials, many contact lens wearers commonly report symptoms such as discomfort by the end of the day. It has been suggested that daily disposable Myopia, or nearsightedness, occurs when the eye is too long and typically worsens as children and young adults grow. The goal of myopia control treatment is to slow this progression, reducing the risk of vision threatening problems later in life. One example of myopia control is the MiSight contact lens, which has been shown by previous research to reduce myopia progression in children aged 8-12. Since some individuals see myopia progression up to age 25, this study is investigating if individuals aged 17-25 can achieve comfort and vision satisfaction with the MiSight lens.

    About the study

    This study consists of 4 in-office appointments and 1 at home remote questionnaire, over 3 months.

    Visit 1 & 2: Screening, baseline measurements and dispense of study lenses – 1.5 hours

    Visit 3: 2 week follow up – 1 hour

    Visit 4: 1 month follow up – 1.25 hours

    Visit 5: 2 month follow up, remote at home questionnaire – 0.25 hours

    Visit 6: 3 month follow up and study exit – 1.5 hour

    Total time commitment5.5 hours

    The study visit includes standard procedures that would often be encountered during a regular eye exam. Please note that physical distancing cannot be guaranteed during all procedures but will be maintained whenever possible.

    What are the requirements?

    To be eligible for this study, you must meet the following criteria:

    •             Aged 17-25

    •             Currently wearing soft contact lenses

    •             Prescription between -0.75 and -6.00 D, with no more than -0.75 D of astigmatism in each eye

    Reimbursement

    In appreciation of the time involved, you will receive $20 per hour, or $110 upon study completion. Parking passes will be provided as required.

    How to participate

    If you are interested in participating, please email corestudies@uwaterloo.ca with the subject line “MULBERRY”. You will be provided with all relevant study information prior to study enrollment, and you are under no obligation to participate.

    Recruiting for a new contact lens study! Study code: COLLIE

    What are we trying to learn?

    Xiidra (lifitegrast 5.0% ophthalmic solution) is a Health Canada approved eye drop that has been shown to be effective in relieving dryness symptoms in individuals with dry eye disease. The purpose of this study is to evaluate changes in comfort and dryness in contact lens wearers after using Xiidra for 12 weeks.

    About the study

    If eligible, you will be asked to follow the study instructions and attend the following visits.

    • Visit 1 – Screening to determine eligibility – 0.75 hour
    • Visit 2 – Baseline measurements and dispense eye drops – 1 hour
    • Visit 3 – 2-week follow-up visit– 1 hour
    • Visit 4 – 6-week follow-up visit– 1 hour
    • Visit 5 – 12-week follow-up visit– 1 hour
    Total time commitment – 4.75 hours
    The visits will include standard clinical procedures that you might encounter when you attend an eye exam.

    What are the requirements?

    • You are 18 years or older
    • You have worn soft contact lenses for a minimum of 5 days/week for 6 hours/day over the past month (and are willing to continue to do so)
    • You experience discomfort (e.g. dryness) when wearing your contact lenses

    Reimbursement

    In appreciation of your time you will receive $95 upon study completion. Parking passes will be provided as required.

    How to participate

    If you are interested in participating, please complete and return the attached questionnaire to corestudies@uwaterloo.ca and write the study ID, “COLLIE”, as the email title. If you have questions or would like more details, please call 519-888-4742. You will be provided with all relevant study information prior to study enrollment and you are under no obligation to participate.

    Safety during COVID-19

    We want to let you know that we have revised several of our protocols to keep participants and researchers safe during the pandemic, including enhanced cleaning and mandatory wearing of masks by everyone. Measures we have taken to reduce the risk of exposure to COVID-19 are explained in the attached “Information Letter: COVID-19 Risks for In-Person Research Study Visits” which we will ask you to sign in the event you participate. Please note that you will be within 2m (6 feet) of the researcher during some or most of the study visit time. At all times, the furthest possible distance will be maintained. Please note, if you are aged 60 and above, you are considered at a greater risk for severe illness from the COVID-19 virus.

    Recruiting for a new children’s myopia control study: MAP

    What are we trying to learn?

    Nearsightedness or “myopia” makes it difficult to see distant objects clearly and requires the use of glasses or contact lenses to achieve good vision. Typically the severity of this myopia increases as children grow, which may increase their risk of vision threatening conditions, such as glaucoma, retinal detachment and blindness later in life. A recent clinical trial of a specially designed contact lenses, called MiSight®, showed significant slowing of myopia progression in children aged 8-12. The MiSight® lens is now commercially available in Canada.

    The purpose of this study is to investigate if a new design of these MiSight® soft contact lenses could provide a greater treatment effect, particularly for children whose myopia progresses quickly.

    About the study

    This study consists of two parts. In Part 1 (the first year), all children will wear the MiSight® myopia control lens, which has been approved for commercial use in Canada. In Part 2 (the final two years), your child will wear one of three lens types, all of which are designed to slow myopia progression. One of these three lens types is MiSight®, the other two lenses are not commercially available but have been approved by Health Canada to be assessed in this study.

    At the beginning of study, you child will be randomly assigned to the type of lenses they will wear during Part 2 of the study.

    Part 1

    • Visit 1a &1b (both visits normally combined): Baseline measurements (3.5 hours) and trial lens fit, dispensing Part 1 lenses (1.5 hours) – total time 5 hours
    • Visit 2: 2-week follow up – 2 hours
    • Visit 3: 3-month follow up – 1.50 hour
    • Visit 4: 6-month follow up –1.75 hours
    • Visit 5: 12-month follow up & dispense Part 2 lenses – 3.75 hours

    Part 2

    • Visit 6: 2-week follow up – 1.75 hour
    • Visit 7: 6-month follow up – 2 hours
    • Visit 8: 12-month follow up – 3.75 hours
    • Visit 9: 18-month follow up – 2 hours
    • Visit 10: 24-month follow up and study exit – 3.75 hours


    Total time commitment
    10 visits for a total of 27.25 hours over 3 years

    The visits will include standard clinical procedures that you might encounter when you attend an eye exam.

    What are the requirements?

    • Children aged 7-11
    • No previous experience with myopia control treatments
    • Prescription range between -0.50 and -4.50 D
    • Willing to wear daily disposable contact lenses 10 hours/day, 6 days/week

    Reimbursement

    In appreciation of your time, you will receive $545 upon study completion. Parking tokens will be provided as needed.  

     How to participate

    If you are interested in participating, or would like to book your first appointment, please contact CORE at 519-888-4742 or email COREstudies@uwaterloo.ca for more information.

    Please provide the study ID “MAP when you call/email. You will be provided with all relevant study information prior to study enrollment and you are under no obligation to participate.

    Safety during COVID-19

    We want to let you know that we have revised several of our protocols to keep participants and researchers safe during the pandemic, including enhanced cleaning and mandatory wearing of masks by everyone. Measures we have taken to reduce the risk of exposure to COVID-19 are explained in the “Information Letter: COVID-19 Risks for In-Person Research Study Visits” which we will ask you to sign in the event your child participates.

    Research Study for Near-sighted Children: HONEYDEW

    Nearsightedness can increase as children grow and the goal of myopia control is to slow down this progression. This study is comparing an investigational daily disposable contact lens designed to control myopia progression to a regular contact lens.

    What would happen if you and your child took part in this study?

    If you both decide to take part in this study you would attend 11 study visits at CORE over 3 years, totaling 30.5 hours. Your child would be fitted with either the study contact lens or a control lens and asked to wear the lenses daily for the duration of the study. In appreciation of your time you will receive $20/hour for attending study visits, up to $650 for study completion. All study products will be provided by CORE.

    Would this study be a good fit for my child?

    This study might be a good fit for your child if

    • They are between 7-12 years of age
    • They have a prescription between -0.75 and -4.50 Dioptre of spherical power with no greater than 1 Dioptre of astigmatism in each eye
    • They have never had myopia control treatment before or participated in a previous myopia control study

    Safety during COVID-19

    We want to let you know that we have revised several of our protocols to keep participants and researchers safe during the pandemic. Measures we have taken to reduce the risk of exposure to COVID-19 are explained in an information letter, which we will send to you should you express interest in participating.

    To take part in the HONEYDEW research study please make a volunteer profile for your child. If you meet the study criteria, you will be provided with all relevant study information prior to study enrollment, and you are under no obligation to participate. If you would like more information about nearsightedness and myopia control click here.

    New myopia study (Study ID: ASH)

    In this study we are assessing how the eyes focus through a novel spectacle lens designed that slow down the progression of myopia (near-sightedness). We want to evaluate how eyes focus with these new lenses, and with two other lenses for comparison. Each pair of spectacles will be worn for approximately 20 minutes each, one after the other at a single study visit.

    About the study

    This study is completed in a single visit. If you/your child is found eligible to continue to the measurement session, you/they will be asked to wear each of the 3 pairs of spectacles for 15-20 minutes each, one after the other. Following 5 minutes adaptation to each pair, some focus measurements will be made.

    •             Screening to determine eligibility                 0.50 hours

    •             Study spectacle wear & measurements       1.25 hours

                             *Total time commitment –   1.75 hours

    The study visit includes standard procedures that would often be encountered during a regular eye exam. No eye drops are used, the equipment does not touch the eyes or use bright lights.

    What are the requirements?

    To be eligible for this study, you must meet the following criteria:

    •             Aged 6-18, inclusive

    •             Currently either wear or require spectacle of low prescription (no more than -0.75 each eye) or are a current contact lens wearer (any nearsighted prescription)

    Reimbursement

    In appreciation of the time involved, you/your child will receive $40 upon study completion. Parking passes will be provided as required.

    How to participate

    If you/your child are interested in participating, please email corestudies@uwaterloo.ca with the subject line “ASH.” You will be provided with all relevant study information prior to study enrollment, and you/your child are under no obligation to participate.

    Safety during COVID-19  

    We want to let you know that we have revised several of our protocols to keep participants and researchers safe during the pandemic, including enhanced cleaning and mandatory wearing of masks by everyone. Measures we have taken to reduce the risk of exposure to COVID-19 are explained in the “Information Letter: COVID-19 Risks for In-Person Research Study Visits” which we will ask you to sign in the event you participate.

    Please note that you/your child will be within 2m (6 feet) of the researcher during some or most of the study visit time.  At all times, the furthest possible distance will be maintained.

    New contact lens study (Study ID: CORGI)

    What are we trying to learn?

    The purpose of this study is to refit wearers of daily disposable contact lenses who currently experience symptoms of dry eye and discomfort during lens wear, with a different type of daily disposable contact lens.

    We will evaluate the performance of your habitual lenses and the study lenses by taking measurements and asking you questions about your lens wearing experience.

    About the study

    If eligible, you will be asked to follow the study instructions and attend the following visits:

    • Visit 1 – Screening to determine eligibility– 1.5 hour
    • 1 week of habitual lens wear
    • Visit 2 – Baseline measurement & study lens dispense – 1 hour
    • 1 month of study lens wear
    • Visit 3 –1-month-follow-up visit & study exist – 1 hour


    Total time commitment4.5 hours (3.5 hours of study visits plus 1 additional hour for at-home ratings)

    The visits will include standard clinical procedures that you might encounter when you attend an eye exam.

    What are the requirements?

    • You are at least 17 years of age
    • You are currently wearing daily disposable contact lenses at least 1 day a week and experience symptoms of dryness or discomfort
    • You are willing to wear daily disposable contact lenses at least 3 days a week for the duration of the study.
    • You are willing and able to follow instructions and maintain the appointment schedule

    Reimbursement

    In appreciation of your time you will receive up to $90. Parking passes will be provided as required.

    How to participate

    If you are interested in participating, please email corestudies@uwaterloo.ca with the subject line: CORGI.  You will be provided with all relevant study information prior to study enrolment and you are under no obligation to participate.