All posts by Barbara McKechnie

OCTOPUS: Seeking non-lens wearers with & without dry eye

Dry eye disease (DED) is a common ocular condition affecting up to 75% of the population and can severely impact patient quality of life. There is a need for more specific tests to diagnosis dry eye disease. The purpose of this study is to investigate the use of an ocular thermography test that measures the surface temperature of the eye using a special camera to diagnose dry eye. It will also assess if a biomarker test that looks at chemical components and antibodies in the tear film can be used to diagnose dry eye.

Both dry eye and non-dry eye participants are being recruited as part of this study. Participants in the non-dry eye group are being invited to join a control group of people without dry eye. Participants in the non-dry eye group will be selected based on their age and biological sex to match a corresponding participant in the dry eye group.

About the study

This study involves 2 study visits, over 2 consecutive days.

  • Visit 1 – Screening and DED assessments – 2.5 hours
  • Visit 2 – Additional DED assessments and study exit – 2.0 hours

Total time commitment for visits = 4.5 hours over 2 days (use of any dry eye treatments/tear drops are not permitted on the study days)  

This study will include 2 in-clinic visits over 2 consecutive days (total = 4.5 hrs) and involve collecting the tear film from your eyes and taking pictures of your eyes with a thermal imaging camera in addition to standard optometric assessments that would occur during an eye exam (including application of an eye drop and procedures that involve something touching the eye).

Participant requirements

  • You are at least 17 years of age
  • You have not worn any contact lenses in the past 6 months
  • You are not experiencing ocular allergies
  • You are not on any allergy medications or any medicated eyedrops
  • You have had an eye exam in the past 2 years
  • Dry eye group: You have a history of DED and/or using tear drops for at least the past 3 months
  • Non-dry eye group: You have no previous history of DED and no history of using any tear drops in the past

Reimbursement

In appreciation of your time, you will receive $20 per hour you are involved in the study ($90 upon completion). Parking tokens are available for those who drive to their visits.

How to participate

If you are interested in participating, please create a volunteer profile at the link below and we will contact you with more information. If you are already a registered CORE volunteer, please email COREstudies@uwaterloo.ca and mention the study name OCTOPUS. You will be provided with all relevant study information prior to study enrollment, and you are under no obligation to participate.

All studies conducted at CORE have been reviewed and received ethics clearance through a University of Waterloo Research Ethics Board.

OTTER 1: Contact lens comfort study testing a new prototype lens

The objective of this study is to evaluate the performance of new prototype contact lenses, with particular focus on comfort.  These lenses have been modified to improve comfort with contact lens wear.

About the study

This study involves 5 study visits across a lens wear period of 2.5 weeks. The study visits are:

  • Visit # 1 – Screening visit to determine eligibility – 1.5 hours
  • Visit # 2 – Baseline measurements and dispensing of pair 1 study lenses – 1 hour
  • Visit # 3 – Follow up visit – 1 hour
    Washout period of up to 6 days where you wear your own glasses or contact lenses
  • Visit # 4 – Baseline measurements and dispensing of pair 2 study lenses – 1 hour
  • Visit # 5 – End of study visit and study exit  – 1 hour

Total in-visit time commitment – 5.5 hours

You will also be asked to complete 2 short questionnaires during the study (5 minutes in total).

The visits will include standard clinical procedures that you might encounter when you attend an eye exam.

Participant requirements

  • You are 18 years of age or older
  • You can be fit with the study contact lenses
  • You habitually wear soft, spherical contact lenses for at least 6 hrs/day, 3 days/week
  • You are willing to wear the study contact lenses for at least 8hrs/day, 5 days/week for the duration of the study
  • You own a pair of glasses that permit participation in daily activities, including safe working and driving

Reimbursement

In appreciation of your time, you will receive $110 upon study completion.

Further information

If you have questions about this study or would like more information, please call us at 519-888-4742 or email us using the link below and mention the study name OTTER 1.

How to participate

If you are interested in participating, please create a volunteer profile at the link below and we will contact you with more information. If you are already a registered CORE volunteer, please contact us using the link below and mention the study name OTTER 1.

All studies conducted at CORE have been reviewed and received ethics clearance through a University of Waterloo Research Ethics Board.

PROTECT: Myopia control study for nearsighted children

Research has shown that early onset of myopia, or near-sightedness, with a moderate amount at a young age, increases the risk for future high degrees of near-sightedness. The goal of myopia control treatment is to slow this progression. In this study, we will be evaluating a daily disposable contact lens designed to slow myopia progression compared with a control lens.


What would happen if you and your child took part in this study?

If you both decide to take part in this study you would attend 9 study visits at CORE over 3 years, totaling 18 hours. Your child would be fitted with either the study contact lens or a control lens and asked to wear the lenses daily for the duration of the study. In appreciation of your child’s time your child will receive $20/hour for attending study visits, up to $360 for study completion. All study products will be provided by CORE.


Would this study be a good fit for my child?

This study might be a good fit for your child if:

• Must be between 7-12 years of age

• Prescription between -0.75 and -5.00 D of spherical power with no greater than 1.00 D of astigmatism in each eye, and less than 1.00 D of difference between the prescription of 2 eyes

• No history of myopia control treatment (eyedrops, spectacles or multifocal contact lenses) or participated in previous myopia control research

• No history of wearing rigid/hard contact lenses or any orthokeratology lenses

• They agree to wear the study contact lenses for a minimum of 10 hours per day, at least 6 days per week, over the study period


Reimbursement

In appreciation of the time involved, you/your child will receive $360 upon study completion. Parking passes will be provided as required.


How to participate

To take part in the PROTECT research study, please make a volunteer profile for your child.

If you meet the study criteria, you will be provided with all relevant study information prior to study enrollment, and you are under no obligation to participate. If you would like more information about nearsightedness and myopia control, click here www.corestudies.ca/myopia

DORY: Seeking adults with & without dry eye

About the study

This study looks to evaluate the diagnostic capabilities of two different devices in relation to dry eye, and how they compare to traditional assessment methods. This study is recruiting individuals with and without dry eye.

  • Visit 1 – Screening visit to determine eligibility & baseline measurements – 2 hours
  • Optional Visit 2 – Repeat of V1 measurements (1-7 days after V1) – 1.5 hours

Total time commitment for visits – Either 2 hours for 1 visit or 3.5 hours over 2 visits

The visits will include standard clinical procedures that you might encounter when you attend an eye exam. 

What are the requirements?

  • You are at least 18 years of age
  • You either don’t wear contact lenses at all, or are able and willing to refrain from wearing contact lenses for 48 hours prior to the study visit(s)
  • This study accepts individuals with and without dry eye

Reimbursement

In appreciation of your time, you will receive $20 per hour that you are involved in the study (up to $70 upon completion for participants who finish both visits). Parking tokens are available for those who drive to their visits.

How to participate

If you are interested in participating, please call 519-888-4742 and mention the study ID “DORY.” You will be provided with all relevant study information prior to study enrollment and you are under no obligation to participate.

STINGRAY: Contact lens study for FRP lens wearers

The goal of this study is to compare the performance of a new, recently-launched contact lens (Total30 by Alcon) to an established product (Biofinity by CooperVision). Each lens will be worn by participants for one month.

About the study

This study consists of 3 in-office appointments over 2 months:

  • Visit 1 & 2 – Screening, lens fitting, baseline measurements and dispense of 1st study lens – 1.75 hours
  • Visit 3 – 1-month follow-up, dispensing of 2nd study lens – 1.25 hours
  • Visit 4 – 1-month follow-up and study exit – 1 hour
  • At-home questionnaires Complete at-home questionnaires on 3 days during each month – 1 hour

Total time commitment – 5 hours

What are the requirements?

To be eligible for this study, you must meet the following criteria:

  • Aged 17+
  • Currently wearing spherical soft contact lenses that are replaced bi-weekly or monthly
  • Are able to wear the study lenses for at least 6 days/week and 8 hours/day during the study
  • Contact lens prescription between -12.00 and +8.00 D

Reimbursement

In appreciation of the time involved, you will receive you will receive $20 per hour, or $100 upon study completion. Parking passes will be provided as required.

Safety during COVID-19

We want to let you know that we have revised several of our protocols to keep participants and researchers safe during the pandemic, including enhanced cleaning and mandatory wearing of masks by everyone. Measures we have taken to reduce the risk of exposure to COVID-19 are explained in an “Information Letter: COVID-19 Risks for In-Person Research Study Visits” which we will ask you to sign in the event you participate.

Please note that you will be within 2m (6 feet) of the researcher during some or most of the study visit time.  At all times, the furthest possible distance will be maintained.

Please note, if you are aged 60 and above, you are considered at a greater risk for severe illness from the COVID-19 virus.

How to participate

If you are interested in participating, please create a volunteer profile at the link below and we will contact you with more information. If you are already a registered CORE volunteer, please email corestudies@uwaterloo.ca and mention the study name STINGRAY. You will be provided with all relevant study information prior to study enrollment and you are under no obligation to participate.

BAGPIPES: Seeking DD hydrogel contact lens wearers

Seeking daily disposable contact lens wearers aged 17-60. Sleeping or napping in contact lenses limits the amount of oxygen reaching the eyes, making the cornea (front of the eye) swell more than it would during waking hours. In this study, we want to simulate sleeping in contact lenses by placing an eye patch over one eye that is wearing a contact lens during waking hours to measure the amount of swelling that occurs.

About the study

If eligible, you will be asked to follow the study instructions and attend the following visits:

  • Visit 1 (DAY 1) – Screening and study measurements – 2.75 hours
  • Visit 2 (DAY 2) – Baseline assessment and lens dispense – 1.25 hours
    *3 hour wait time between Visit 2 & 3 with eye patch covering one eye*
  • Visit 3 – Lens removal after 3 hr wait time and measurement taken (same day)
  • Visit 4 – Measurement taken after 0.5 hr from removal (same day)
  • Visit 5 – Measurement taken after 1 hr from removal (same day)
  • Visit 6 – Measurement taken after 2 hr from removal (same day)
  • Visit 7 – Measurement taken after 3 hr from removal then study exit (same day)
    *Visits 3-7 will take 4.5 hours

Total time commitment 11.5 hours over 2 days

The visits will include standard clinical procedures that you might encounter when you attend an eye exam.

What are the requirements?

  • To be eligible for this study, you must meet the following criteria:
  • Must be between 17-60 years of age
  • Have proof of eye examination within the last 2 years
  • Prescription between +4.00 and -8.00
  • No previous history of overnight contact lens wear
  • Have worn either spherical hydrogel or spherical silicone hydrogel contact lenses for the past 3 consecutive years with wearing daily disposable contact lenses of the same material type (hydrogel or silicone hydrogel, respectively) currently and at least in the past 6 months. 
  • Are currently not pregnant or nursing a child
  • Have NOT undergone eye surgery
  • Have a habitual contact lens wear schedule of at least 8 hrs a day, 5 days a week
  • Have a wearable pair of spectacles

Reimbursement

In appreciation of the time involved, you will receive up to $230. Parking passes will be provided as required.

Safety during COVID-19

We want to let you know that we have revised several of our protocols to keep participants and researchers safe during the pandemic, including enhanced cleaning and mandatory wearing of masks by everyone. Measures we have taken to reduce the risk of exposure to COVID-19 are explained in an “Information Letter: COVID-19 Risks for In-Person Research Study Visits” which we will ask you to sign in the event you participate.

Please note that you will be within 2m (6 feet) of the researcher during some or most of the study visit time.  At all times, the furthest possible distance will be maintained.

Please note, if you are aged 60 and above, you are considered at a greater risk for severe illness from the COVID-19 virus.

How to participate

If you are interested in participating, please create a volunteer profile at the link below and we will contact you with more information. If you are already a registered CORE volunteer, please email corestudies@uwaterloo.ca and mention the study name BAGPIPES. You will be provided with all relevant study information prior to study enrollment and you are under no obligation to participate.

SETTER: Seeking contact lens wearers for ocular imaging

What are we trying to learn?

Specific cells found in the cornea (the front surface of the eye) play an important role in keeping our eyes healthy.

The purpose of this study is to measure these specific cells in participants who normally wear contact lenses. We are looking for participants who experience discomfort while wearing their lenses, and those who do not experience any discomfort with lens wear.

About the study

You will be wearing your own contact lenses throughout this study. This study will be conducted over approximately 3 weeks. There are 10 study visits, which occur on 6 study days. The study visits are:

  • Day1:
    o Visit #1 – Screening visit to determine eligibility (45 minutes)
  • Day 2: No contact lens wear on this day (1.5 hours total)
    o Visit #2 – Eye imaging (45 minutes)
    o Visit #3 –Eye imaging 8 hours after Visit 2 (45 minutes)
  • Day 3: Contact lenses to be worn for 1 hour prior to appointment
    o Visit #4 Eye imaging (45 minutes)
  • Day 4: Contact lenses to be worn for 4 hours prior to appointment
    o Visit #5 – Eye imaging (45 minutes)
  • Day 5: Contact lenses to be worn for 8 hours prior to appointment
    o Visit #6 – Eye imaging (45 minutes)
  • Day 6 Contact lenses to be worn all day (1.75 hours total)
    o Visit #7 – Eye imaging 1 hour after lens insertion (30 minutes)
    o Visit #8 – Eye imaging 4 hours after lens insertion (30 minutes)
    o Visit #9 – Eye imaging 8 hours after lens insertion and study exit (45 minutes)

Total time commitment 6.5 hours

The visits will include standard clinical procedures that will touch your eyes that you might encounter when you attend an eye exam.

What are the requirements?

  • You are at least 17 years of age
  • You habitually wear soft contact lenses at least 5 days per week, 8 hours per day
  • You have worn contact lenses on a daily wear basis for the past 12 months

Reimbursement

You will receive up to $130 for the completion of all study visits. If you drive to your appointments, parking tokens will be provided.

How to participate

If you are interested in participating, please complete and return the attached questionnaire to corestudies@uwaterloo.ca and use the study code name SETTER as the email subject. If you have questions or would like more details, please call 519-888-4742. You will be provided with all relevant study information prior to study enrollment and you are under no obligation to participate.

Safety during COVID-19

We want to let you know that we have revised several of our protocols to keep participants and researchers safe during the pandemic, including enhanced cleaning and mandatory wearing of masks by everyone. Measures we have taken to reduce the risk of exposure to COVID-19 are explained in an “Information Letter: COVID-19 Risks for In-Person Research Study Visits” which we will ask you to sign in the event you participate.

Please note that you will be within 2m (6 feet) of the researcher during some or most of the study visit time.  At all times, the furthest possible distance will be maintained.

Please note, if you are aged 60 and above, you are considered at a greater risk for severe illness from the COVID-19 virus.